🔬 Science 5d ago · Ben Sullivan

Why Fructose Behaves Less Like a Calorie and More Like a Hormone

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Drop a gram of fructose into a human liver cell and something strange happens in the first few seconds. An enzyme called ketohexokinase grabs it, slaps a phosphate onto the first carbon, and sets off a small metabolic fire. ATP, the cell’s energy currency, drains faster than the cell can make more of it. Uric acid spikes. A lipogenic signal fans out. All this, from a sugar that, calorie for calorie, is identical to the glucose sitting in your bloodstream right now.
That paradox, that fruct

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