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1d ago
Cell-level analysis reveals how ovarian tumors may develop resistance to chemotherapy
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High-grade serous ovarian cancer is an aggressive form of ovarian cancer, characterized in particular by high diversity among the cells that compose a given tumor. This intratumor heterogeneity is a major challenge in understanding why some tumors respond to treatments and others resist. Additionally, this diversity is not limited to genetic differences: tumor cells that have similar genetic profiles may have different functions, depending on the genes they express and their epigenetic state.
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