C. diff coordinates threat response to survive in gut
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The pathogen Clostridioides difficile (C. diff) — a leading cause of hospital-acquired infections — must contend with a variety of threats inside the harsh environment of the gut to survive and grow.
Researchers at Vanderbilt Health have now discovered a unique system C. diff uses to simultaneously sense and respond to two different threats: host-mediated nutrient deprivation and a microbiota-produced antibiotic compound. Their findings, published Sept. 8 in Science Signaling, suggest new the
Researchers at Vanderbilt Health have now discovered a unique system C. diff uses to simultaneously sense and respond to two different threats: host-mediated nutrient deprivation and a microbiota-produced antibiotic compound. Their findings, published Sept. 8 in Science Signaling, suggest new the
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