The runner’s high was attributed to endorphins for decades, but circulating endorphins cannot readily cross the blood–brain barrier—and blocking opioid receptors does not prevent runners from feeling euphoric. Evidence now points primarily to endocannabinoids, the body’s cannabis-like signalling molecules, although the full high probably involves several interacting brain systems.
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The runner’s high is usually described as one feeling caused by one chemical. The experience is less orderly. Some runners report euphoria. Others notice quiet, reduced anxiety, muted pain, altered time or an effortless urge to continue. Many finish a long run without anything they would call a high.
For decades, endorphins supplied the standard explanation. Exercise can raise beta-endorphin in the bloodstream, and opioids are closely associated with pain relief and reward. But circulating beta-
For decades, endorphins supplied the standard explanation. Exercise can raise beta-endorphin in the bloodstream, and opioids are closely associated with pain relief and reward. But circulating beta-
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