New Form of Brain Cell Death May Explain How Dementia Destroys Neurons
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Inside a dying brain cell, the first thing to go is the nucleus. Not the whole cell at once, not some tidy programmed shutdown, but the nucleus itself: the membrane around it buckles, the smooth sphere puckers and shrivels like fruit left too long in a bowl, and then it falls apart. Researchers at King’s College London have a name for this. They call it karyoptosis, and they think it accounts for a great deal of the neuronal loss that has long been pinned, rather vaguely, on dementia.
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