🔬 Science Jun 25, 2026 · Ben Sullivan

A Single Gut Bacterium Eases Lupus in Mice by Restoring How the Microbiome Digests Fiber

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Deep in the colon, where there is no oxygen and no light, a bacterium called Faecalibacterium prausnitzii spends its life breaking down the fiber you ate for lunch. It is one of the most abundant microbes in a healthy human gut, and one of the most useful. Strip it out, and the whole neighborhood shifts: less fiber gets fermented, fewer calming compounds get made, and the gut wall starts to fray. In people with lupus, that bacterium is conspicuously missing.
Now researchers at UT Health San Anto

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