Alzheimer’s Gene Doesn’t Behave the Same Way in Everyone
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On a PET scan, amyloid shows up as a wash of colour across the cortex, brighter where the sticky protein has gathered into plaques. For decades the reading of those scans has rested on a tidy assumption: carry the APOE ε4 gene variant, the strongest common genetic risk factor for late-onset Alzheimer’s, and your brain is far more likely to light up. More amyloid, more risk. The logic felt close to mechanical. A new analysis of more than 17,000 older adults suggests the machinery is not so
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