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7h ago
3D genome architecture pre-wires early developmental decisions
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New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding that brings remote DNA regulatory regions into physical contact with genes they control. This work, from a team at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London, with collaborators from the Babraham Institute in Cambridge, shows that some of these contacts form long before ge
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