Tiny Brain Cells Hold the Key to Faster, Safer Antidepressants
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Deep in the prefrontal cortex, a small population of neurons is doing something that shouldn’t be happening. Under chronic stress, these cells (called somatostatin interneurons) grow larger, extend more synaptic connections, and clamp down on the surrounding circuitry with increasing force. The result is a kind of neural silencing: the prefrontal cortex, a region critical to emotion regulation and decision-making, goes quiet. Not because its principal cells are broken, exactly, but because
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