🔬 Science 9h ago · Ben Sullivan

Your Morning Coffee May Be Activating a Protein That Fights Aging

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At a binding affinity of roughly 1.2 micromolar, caffeic acid locks into a protein called NR4A1 with a grip that most pharmaceutical researchers would find encouraging. It is not a drug. It is, more or less, what you get when you brew coffee.
Stephen Safe, a toxicologist at Texas A&M University who has spent years probing how diet shapes disease, noticed the overlap a while back and couldn’t quite let it go. Why, exactly, does coffee keep turning up in epidemiological studies as a prot

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