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5d ago
ALS may stem partly from failed protein cleanup in motor neurons
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which in most cases leads to respiratory failure within three to five years after diagnosis. In this context, a team from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University (UMH) and the Spanish National Research Council (CSIC), has identified that a cellular "selective cleaning system" for proteins: chaperone-mediated autophagy, is significan
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