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6h ago
Captured mid-reaction, RNA polymerase reveals universal blueprint for gene transcription
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The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life. But the inner workings of this essential enzyme have long baffled scientists. Trying to work out how it performs its core chemical reaction, which stacks new RNA building blocks one nucleotide at a time, has proven especially difficult.
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